Technetium and Copper Complexes for Diagnostic Imaging of Neurodegeneration

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

XY Choo, LE McInnes, A Grubman, JM Wasielewska, I Belaya, E Burrows, H Quek, JC Martín, S Loppi, A Sorvari, D Rait, A Powell, C Duncan, JR Liddell, H Tanila, JM Polo, T Malm, KM Kanninen, PS Donnelly, AR White

2022-09-01

Neuroinflammation has a major role in several brain disorders including Alzheimer’s disease (AD), yet at present there are no effe..

Oxorhenium(V) and Oxotechnetium(V) Complexes of N3S Tetradentate Ligands with a Styrylpyridyl Functional Group: Toward Imaging Agents to Assist in the Diagnosis of Alzheimer's Disease

B Spyrou, IN Hungnes, F Mota, J Bordoloi, PJ Blower, JM White, MT Ma, PS Donnelly

2021-09-06

Alzheimer's disease (AD) is associated with the presence of amyloid plaques in the brain mainly comprised of aggregated forms of a..

Copper Bis(thiosemicarbazonato)-stilbenyl Complexes That Bind to Amyloid-β Plaques

A Noor, DJ Hayne, SC Lim, JK Van Zuylekom, C Cullinane, PD Roselt, CA McLean, JM White, PS Donnelly

2020-08-17

Alzheimer's disease is characterized by the presence of extracellular amyloid-β plaques. Positron emission tomography (PET) imagin..

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups

Brett M Paterson, Carleen Cullinane, Peter J Crouch, Anthony R White, Kevin J Barnham, Peter D Roselt, Wayne Noonan, David Binns, Rodney J Hicks, Paul S Donnelly

2019-04-01

The synthesis of new bis(thiosemicarbazonato)copper(II) complexes featuring polyamine substituents via selective transamination re..

Potential Diagnostic Imaging of Alzheimer's Disease with Copper-64 Complexes That Bind to Amyloid-β Plaques

LE McInnes, A Noor, K Kysenius, C Cullinane, P Roselt, CA McLean, FCK Chiu, AK Powell, PJ Crouch, JM White, PS Donnelly

2019-03-04

Amyloid-β plaques, consisting of aggregated amyloid-β peptides, are one of the pathological hallmarks of Alzheimer's disease. Copp..

Rhenium and technetium complexes of thioamide derivatives of pyridylhydrazine that bind to amyloid-β plaques

SP Fletcher, A Noor, JL Hickey, CA McLean, JM White, PS Donnelly

2018-10-01

Abstract: Age-associated deposition of amyloid-β in cerebral blood vessels, a condition referred to as cerebral amyloid angiopathy..

Effect of Structural Modifications to Glyoxal-bis(thiosemicarbazonato)copper(II) Complexes on Cellular Copper Uptake, Copper-Mediated ATP7A Trafficking, and P-Glycoprotein Mediated Efflux

KM Acevedo, DJ Hayne, LE McInnes, A Noor, C Duncan, D Moujalled, I Volitakis, A Rigopoulos, KJ Barnham, VL Villemagne, AR White, PS Donnelly

2018-02-08

Bis(thiosemicarbazonato)copper(II) complexes are of interest as potential therapeutics for cancer and neurodegenerative diseases a..

Guest-induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes

Brett M Paterson, Keith F White, Jonathan M White, Brendan F Abrahams, Paul S Donnelly

2017-07-10

A ZnII complex of the dianionic tetradentate ligand formed by deprotonation of glyoxal‐bis(4‐phenyl‐3‐thiosemicarbazone) (H2gtsp) ..

Guest‐induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes

Brett M Paterson, Keith F White, Jonathan M White, Brendan F Abrahams, Paul S Donnelly

2017-07-10

<jats:title>Abstract</jats:title><jats:p>A Zn<jats:sup>II</jats:sup> complex of the dianionic tetradentate ligand formed by deprot..

A one-pot route to thioamides discovered by gas-phase studies: palladium-mediated CO2 extrusion followed by insertion of isothiocyanates

Asif Noor, Jiawei Li, George N Khairallah, Zhen Li, Hossein Ghari, Allan J Canty, Alireza Ariafard, Paul S Donnelly, Richard AJ O'Hair

2017-04-07

A new palladium mediated “one pot” synthesis of thioamides from aromatic carboxylic acids (ArCO2H + RNCS → ArC(S)NHR + CO2) was di..

The efficient synthesis and purification of amyloid-β(1-42) using an oligoethylene glycol-containing photocleavable lysine tag

JA Karas, A Noor, C Schieber, TU Connell, F Separovic, PS Donnelly

2017-01-01

A short, monodisperse oligoethylene glycol-containing photocleavable lysine tag was developed to facilitate the efficient purifica..